She was born on September 28, 2000, to parents Dave and Shannon D'Amico. The family resides in America and has American nationality. Brenna D'Amico was born and raised in Chicago, Illinois. She has a sister named Aubree. She plays guitar and piano in her free time. The actress has taken LA Casting Director Workshops training.
- She can also play the piano and the guitar.
- In real life, she was dating her co-star Cameron Boyce since 2015, but they seem to have broken up in 2016-2017.