Sneezy is first introduced, with his six companions, at the Dwarfs' Mine. He, Grumpy, Bashful, and Happy dig to unearth diamonds from the tunnels. The diamonds are taken by Sleepy to Doc, who puts the valuable diamonds in bags to keep and discards the worthless diamonds for Dopey to sweep away. Doc is the first to hear the alarm and alerts the other dwarfs that it is time for them to go home. Sneezy is the sixth in line as the dwarfs sing "Heigh-Ho".
When the seven dwarfs reach their cottage, Doc suddenly stops (causing the six other dwarfs to pile up behind him), noticing that light is coming from the house. The dwarfs think that a monster has taken up residence in their house. They sneak into the cottage; Doc, holding a candle, tells them to search everywhere. The dwarfs note that the cottage has been cleaned. At one point Sneezy and Sleepy check the sink, discovering it is empty and Sneezy informs the others that their dishes have been stolen, but Happy corrects him and says that their dishes are now in the cupboard, cleaned. Bashful sees some flowers and shows them to Sneezy; being allergic, he starts to utter, "Don't do it. My nose. My hayfever. You know that I can't stand it." The other dwarfs cover his nose. He says as his catchphrase, "Aww, thanks!" However, that does not really help; he lets fly a giant sneeze, blowing his companions across the room. Grumpy, frowning and angrily calling him a crazy fool, starts to tell Sneezy to which he replies, "I couldn't help it, I can't tell. When you gotta, you gotta. I.... I gotta--it's coming," and shows signs of sneezing, prompting the other dwarfs to jump on him and tie his beard in a hard knot around his nose to keep him quiet, forming a sort of "mustache"; this succeeds.
They decide that whatever is in the cottage is upstairs. They are about to strike whatever is sleeping in their beds when they realize that it is the princess, Snow White. Sneezy is the first to comment on how pretty she is. Grumpy begins to complain, and Doc attempts to silence him, but Snow White is woken up. She manages to match the name at the foot of each bed to the correct dwarf, identifying Sneezy fourth, due to the fact he is about to sneeze. Doc attempts to express his delight, but is flustered, and gets into an argument with Grumpy, who wants Snow White to leave. Eventually, it is agreed that Snow White will clean and cook for the dwarfs if she is allowed to stay.
She prepares soup for them but demands that they wash first. Grumpy follows the dwarfs outside but refuses to wash. When Sneezy checks the tub full of water, he dips his finger in the water. He blubbers, shocking the other dwarfs, and the water is cold. The other dwarfs, led by Doc, manage to drag him to the water and wash him thoroughly while singing "Bluddle-Uddle-Um-Dum (The Dwarfs' Washing Song)".
Later that evening, after supper, the seven dwarfs entertain Snow White with the "Silly Song", Sneezy yodels a long verse while a transfixed Dopey watches his Adam's apple bob up and down vigorously. Dopey then attempts to perch on Sneezy's shoulders wearing a long trench coat which almost makes Sneezy sneeze, but Dopey prevents it by holding Sneezy's nose with his feet, and they fumble on to dance with Snow White. Right at the climax of the song, Sneezy, with Dopey still on shoulders starts jittering both his words and his movements, peering through the bottom half the coat to warn his brothers and Snow White that a sneeze is on the way. Everybody dives for cover just as Sneezy jitters some more before letting out the huge sneeze from earlier, thus inflating the coat which causes Dopey to pop out of the top letting the coat slow sink down to reveal Sneezy's smiling face. This gives everyone a good laugh.
After they finish the song, the dwarfs listen to Snow White sing "Some Day My Prince Will Come", which sends every dwarf, except the stubborn, defiant Grumpy, into a dream-like state. Doc declares that Snow White will sleep in the bedroom upstairs, and the dwarfs must sleep downstairs. Sneezy sleeps next to Dopey, using his buttocks as a cushion. During the night, Dopey starts whimpering in his sleep and kicking his legs, but a few jabs from Sneezy makes him settle.
The next morning, Snow White kisses each dwarf farewell as he leaves for the mine. A kiss from Snow White is able to prevent one of Sneezy's sneezes. Just before it returns, he manages to say, "Aww, thanks!" Nevertheless, the power of the resounding sneeze is enough to blow Dopey back inside the cottage. While the dwarfs head to the mine, the Evil Queen, as the Witch, makes her way to the cottage, knowing that only Snow White will be at home. As she finds the Princess baking a gooseberry pie for Grumpy, the animals sense danger and, after attempting to drive her away, rush to the mine to fetch the dwarfs. When they discover that the Queen has found Snow White, the dwarfs rush home to find that the disguised Queen has succeeded in poisoning the Princess and is about to leave. The dwarfs, led by Grumpy, chase the Queen into the mountains, and she reaches a cliff. She attempts to crush the dwarfs with a boulder, but a flash of lightning causes her to fall from the cliff and be crushed by the boulder herself.
The seven dwarfs mourn Snow White's death; Sneezy is shown silently weeping with Bashful and Sleepy. The dwarfs find her to be so beautiful, even in death, that they fashion a coffin from glass and place her inside. The handsome Prince arrives, and the dwarfs part so that he can approach Snow White. He kisses her, breaking the spell of the Sleeping Death, and the dwarves cheer (with Sneezy being the second to notice her awakening). Just before Snow White leaves with the Prince, she kisses each dwarf on the forehead (Sneezy was 4th).
- In School of Secrets, he is given the phone to talk to Doug by Doc, but suddenly sneezes on the phone which made Doug disgusted from the noise.